Estrogen Disrupting Pesticides in Nebraska Groundwater: Trends between Pesticide-contaminated Water and Estrogen-related Cancers in An Ecological Observational Study

Estrogen disrupting pesticides (EDP) are that modify estrogen activities in estrogen-producing vertebrates. A substantial amount of these has been detected human tissues, and they function directly to disrupt synthesis or effector cells. This study examines EDP’s ecological distribution across Nebraska counties its association with estrogen-related cancers (ERC). To determine the selected EDP, county-level choropleth maps were created. Moreover, EDP was tested separate linear models different ERC between counties. Exposure data for this obtained from quality assessed agrichemical contaminant groundwater database 1 January 1974 31 December 2012. Acetochlor, atrazine, metabolites, deethylatrazine (DEA), de-isopropyl atrazine (DIA) most frequently groundwater. potential confounder such as physically unhealthy days, % adult smoking, obese adult, uninsured, binge drinking County Health Rankings 2010. ERC, which is outcome variable (breast cancer, uterine prostate cancer), State profile National Cancer Institute. expressed age-standardized incidence cancer rates 2013 2017. Data characteristics determined using percentages, mean, median, 25th 75th percentile, minimum maximum values. The relationship wells positive after adjusting county level confounders analyzed a regression model. Water supply DEA observed cluster South East Nebraska. Furthermore, breast higher southeast more DEA. However, not significantly associated model any EDP. In contrast, statistically water acetochlor (β = 4.01, p 0.04). While consistent associations GIS model, study’s results can drive future conversation concerning estrogenic effects acetochlor, metabolites on breast,